This paper discusses the practice of self-mutilation. It is based on the case of a patient named Virginie. By considering this patient’s speech, this paper views this practice in the light of Lacan’s teachings on the sacrifice. As a sacrificial act, the ritual of self-mutilation gives the other the condition of the sacred: it is a subjective operation that brings a calming response to the question of the desire of the other. The patient is dealing with a collapse in the passage to the fantasy in which the lack of the other is denied. Therefore, self-mutilation (which plays out between the symbolic and the real) expresses the impossibility of losing the object.